Hemosiderosis

Hemosiderosis calls for storing large amounts of hemosiderin in the organ. Hemosiderin is a protein that stores iron in the body, is a derivative of hemoglobin released during hemolysis (destruction of erythrocytes). Hemosiderosis be recognized macroscopically and in the liver, spleen, pancreas, lymph nodes, etc., ochraceous color. Given to these organs. Histology mainly hemosiderin granules in the cells of the reticuloendothelial system, but also in liver cells in the epithelial cells uriniferous tubes (nephrons, etc.).

Hemosiderosis can be observed as a result of repeated blood transfusions are very broad (transfusional Siderosis) and diseases accompanied by intense blood damage, especially in pernicious anemia. In the lungs also saw marked hemosiderosis, as a result of stasis in the smaller circle has taken a lot of small volume bleeding. Alveolar epithelial then phagocytosed red blood cells to form hemosiderin. When they were expelled in sputum, which is the so-called cardiac cells (cell lesions of the valve), the process is particularly seen in patients with heart valve lesions (mitral valve disease).