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12/10/2012

Ganglion

Ganglion is a small cystic swelling (not cancer), 2 to 3 cm. It originated in the cavity of the joint or tendon sheath, usually in the wrist but sometimes on foot or knee. From the standpoint of pathology, ganglion is occupied by a wall of fibrous collagen and slimy liquid. Considered to arise as a result of local myxoid degeneration of connective tissue or caused by trauma, such as sprains. Ganglion is usually painless and go, but the treatment.

Rhabdomyosarcoma

Rhabdomyosarcoma is a fast growing and highly malignant tumor striated muscle. We can identify three distinct clinical and histologic: 1) pleomorphic adults (about 15%), which means it can take different forms, 2) embryonic alveolar (45%), 3) botrioideo embronario (40%). Rhabdomyosarcoma is generally aggressive tumors, early stage widespread, with metastases in the lungs, pleura, mediastinum and pericardium.  

Pleomorphic rhabdomyosarcoma occur in men and women, usually between 30 and 40 years. Attacks most commonly the lower extremities, usually the thigh muscles, such as quadriceps, adductor and semimembranosus. The tumor grows quickly and can reach even 25 cm in diameter. The tumor is located deep in the muscles and soft tissues are composed of grayish red meat and fish-like, with a focus of necrosis and hemorrhage. Because these tumors are pleomorphic, with light can be observed microscopically different types of cells, the cells are sometimes racket prolongations protoplasm unique and long, sometimes giant cells with peripheral vacuoles oval band separated by a thin cytoplasm (cell cobweb), but be- liver cell layer usually clearly distinguished from variable dimenciones.  

Embryo alveolar rhabdomyosarcoma occurs almost exclusively in children and usually appears at the upper or lower extremities, but sometimes involving the trunk. Macroscopic rhabdomyosarcoma has aspects similar to adults, but rarely reach such large dimensions. In a histological study warns cellular round to oval shape, and the similarity suggests occasional slightly elongated muscle cells mature. The cells are arranged in small nests or rosette, separated by fibrous stroma interlace, frame holds some resemblance to images of lung alveolar cells and alveolar cavity neoplastic occupy, provide a name for this type of tumor.  

Botrioideos embryonal rhabdomyosarcomas usually occurs in children and young adults and attacked several sites, for example, genitourinary, biliary tract and orbit. Skeletal muscle is rarely attacked.

Chlorosis (female)

Chlorosis is a disease that occurs in women during the developmental maturity, which consists exclusively of decline in the proportion of hemoglobin in the blood. Chlorosis is widespread among young women in the late nineteenth century. Perhaps chlorotic condition starts very early during embryonic life or during early childhood, but it occurs in young people 12-18 years and associated with ovarian and menstrual cycles. What is striking in this patient was pale, sounding completely white, and ease of fatigue, the lips acquire grayish and the tongue has a bluish gray color.

Symptoms include fatigue and tiredness a bit of effort, the weight of the leg, dyspnea when climbing stairs, scintillating scotoma, headache, cold hands and feet, and menstrual disorders may be amenorrhea, vaginal discharge, and constipation. In more severe cases of chlorosis occurs relative lack of mitral and tricuspid valves. Changes in the characteristics present chlorosis CBC: real hyperchromic anemia, which decrease the proportion of hemoglobin in the blood. The number of erythrocytes is usually normal, but occasionally the upper and lower figures, but the most important change is the proportion of low hemoglobin, which usually varies between 70 and 15%. Therefore, also in the globular value, the amount is less than 0.7, generally varies between 0.5 and 0.6.

In colored extensions poikilocytosis surprising and above all great pale red blood cells. In preparation stained erythrocytes observed some polychromatophils, while in chlorosis, not usually found red blood cells with basophilic granulation. Chlorosis is a chronic condition that can last for several years, more than eight, but the direction is usually seen, usually associated with the treatment and the time of year, it becomes visible annoyance to early spring and early autumn improvement.

Myotonic Dystrophy

Myotonic dystrophy, also called Curschmann and Steiner disease is a condition in which muscle atrophy associated with myopathy Thomsen type myotonia and hereditary endocrine disorders. Myotonic dystrophy is a hereditary and family, are more common in men than in women, and the observation of a rare degenerative. Started between 20 and 30 years. The patients had a family history of properties such as high infant mortality, many abortion, sterility, cataracts the beginning of each successive generation.

In myotonic dystrophy, the affected muscles showed a gradual loss of longitudinal and transverse striation and infiltration of the muscle fibers and fat drops of nuclear proliferation. While in the nervous system have been checked degenerative lesions in the diencephalon, and the vegetative nucleus splanchnic nerve, lateral and anterior horn of the spinal cord and posterior. Muscle atrophy that occurs in this disease occurs in the neck, face and distal limbs, myopathy kind uncontracted fibrils.

The condition occurs in myotonic hand, sternocleidomastoid muscle and eyelid. Endocrine and dystrophic signs of premature baldness comprise, eye cataracts, testicular atrophy, mumps, kyphosis or lordosis, with or without hypothyroidism, hypogonadism. The prognosis is not good, as the disease progresses slowly and patients end up as myopathy.

Hair Cells (Ear)

Hair cells sensory cells that are part of the organ of Corti is located in the cochlea in the inner ear. Extension has a very thin, hair-shaped, estereocilias called, stand on the middle level are in contact with endolymph. The function of the hair cells is to convert sound vibrations into nerve impulses that travel to the occipital lobe of the brain via the auditory nerve.

Organ of Corti

Spiral structure of the organ of Corti is formed by the hair cells and supporting neuroepithelial cells. Lying on the basement membrane in the bottom half of the scale, along the cochlea of the inner ear canal, forming a spiral. One can say that the organ of Corti is the auditory center, because it is a place where sound waves are converted into pulses nervisos.

Vertical cut the cochlea which houses the organ of Corti

12/09/2012

Hemosiderosis

Hemosiderosis calls for storing large amounts of hemosiderin in the organ. Hemosiderin is a protein that stores iron in the body, is a derivative of hemoglobin released during hemolysis (destruction of erythrocytes). Hemosiderosis be recognized macroscopically and in the liver, spleen, pancreas, lymph nodes, etc., ochraceous color. Given to these organs. Histology mainly hemosiderin granules in the cells of the reticuloendothelial system, but also in liver cells in the epithelial cells uriniferous tubes (nephrons, etc.).

Hemosiderosis can be observed as a result of repeated blood transfusions are very broad (transfusional Siderosis) and diseases accompanied by intense blood damage, especially in pernicious anemia. In the lungs also saw marked hemosiderosis, as a result of stasis in the smaller circle has taken a lot of small volume bleeding. Alveolar epithelial then phagocytosed red blood cells to form hemosiderin. When they were expelled in sputum, which is the so-called cardiac cells (cell lesions of the valve), the process is particularly seen in patients with heart valve lesions (mitral valve disease).

Cochlea

The cochlea is the auditory portion of the inner ear, because it is the organ of Corti. It has a spiral structure, with the emergence of a small spiral, and embedded in the temporal bone. The cochlea is divided into three tubular cavity running the spiral staircase: the scala vestibuli, scala media, and scala tympani, the first and the last one is filled with a liquid called perilimfe, but scala media is filled with endolymph, the other fluid types. Vestibuli The scala and scala tympani are connected at the top of the cochlea (the snail), a type of ship called helicotrema communicate. Organ of Corti, which contains neuroepithelial hair cells, the vibrations are transmitted to the cochlea with the bracket through fenestra ovalis (oval window), into nerve impulses that are picked up by the auditory nerve.

12/08/2012

Soft Tissue Fibrosarcoma

Soft tissue fibrosarcoma tumor was malignant tissue. These tumors occur for some time with the good looks fool, which contrasts with the real structure with a large tendency for late recurrence and generalizations. Therefore the interest of early detection. These fibroids develop in filling network and support from all parts of the body: partition and fascias involve muscles, nerves and vessels, showed marked propensity for the extremities. Originally presented as a solitary tumor, the volume varies from size of a walnut to the size of a small orange, but eventually reach a much larger dimension.

In the surgical specimen, the soft tissue fibrosarcomas were packed solid mass. However, the envelope, which is constant, there are barriers that isolate different conjunctiva but is formed by the surface layer of the same tumor, level and strong. They have a very encuenta data, as described excision successive relapse and need extensive subcapsular tumor excision. Mass itself, the court is homogeneous, firm, fibrous appearance and a matte white or grayish white. It consists of connective fusiform cells with large nuclei, without proper guidance, but tend to be arranged around the blood vessels in the wall where they belong. The ship was disorganized, branched, of different calibres.

 Recurrence-law, where, after a simple excision, is characteristic of the soft fibroma, a deceptive ease of removal, but after a variable period of full years, almost always new tumor appears under the surgical scar. This tumor recurrence showed a greater tendency to proliferate, as if the transaction had the potential latent elevated her virulent. Thus, the way to the root of the groin, leg or armpit. Therefore it is said, with a sense of mnemonic, this tumor has a "geotropism" negative. The tumor again and again. Progress of the disease and amputations imposed pathology report in the end, the only way to prolong life for some time.

Rhabdomyoma

Rhabdomyoma is a benign tumor composed of striated muscle fibers. It's big and rich fibrils in the cytoplasm of the cell membrane is drawn, which is fixed to it only at some point, when practicing the entry paraffin. Consequently blisters cytoplasmic core center, which emits a thin extension comparable to the spider legs. When developing myocardium reached Rhabdomyomas measuring 2 cm in diameter and were observed in combination with brain lesions (TSC) and the kidneys.

Tumor Cells and Tissue Matrix

Tumor cells can differentiate stem cells that come in almost all important manifestation, but also can preserve many of their properties. As the way we understand the important manifestation, a particular function, metabolism, trasplantabilidad, etc., Image of different species is highly polymorphic tumor.

A) With respect to morphology, tumor cells often retain all the morphological characteristics of their ancestors, and at other times they do not like it at all. Typically, a slow-growing tumor that is structurally most similar to normal tissue (tumor ripe), while growing rapidly have little morphological peculiarities. They remind us of the cells and tissues of the embryo, are also growing rapidly, although it is understood that they are not embryonic cells. In this case too immature and tumor cell dedifferentiation (anoplasia).

B) What is the function of specific tumor tissue is closely related to the same morphological characteristics: the higher the similarity of morphological tumor to normal tissue, the more likely it is also mimic certain functions. This refers primarily to a large number of tumors of endocrine organs. Anyway, there is a parallel force between tumor differentiation and function. In adult tumors usually have a specific function.

C) tumor cells, such as the previous array are affected by specific substances from the organism itself. In the same way that normal prostate or breast tissue responds to hormones, certain tumor tissues before reacting hormĂłnicas excitations as well, and this has been used in therapy.

D) Another important point is that related to the metabolism of tumor cells. All tumors, especially rapidly growing epithelium, behave similarly to embryonic tissue or injured tissue, which is formed at the expense of glucose lactic acid even in the presence of oxygen.

Reissner Membrane

Reissner membrane is a thin membrane that separates two of the three internal parts of the cochlea: medium-sized vestibular scale. It consists of two layers of flattened epithelial tissue, separated by a basal lamina. The upper layer of Reissner's membrane epithelium at the base of the scala vestibuli, which is immersed in a fluid called perilimfe, while the bottom layer, on the roof of the scala media is impregnated endolymph fluid filled cochlea scala media.

Labyrinth

The inner ear is the part of the ear is in the temporal bone. It is composed of three parts: the cochlea, vestibule and semicircular canals. It is a center for hearing and balance. The inner ear is connected to the middle ear through the bracket, which transmits sound vibrations to the cochlea to the ear drum are collected via the oval window. Thanks to the internal fluid cochlea (perilimfe and endolymph), acoustic vibrations are converted into acoustic waves, which are processed, in turn, into nerve impulses by the organ of Corti, the last, which is located in the cochlea scala media, contains hair cells that make this possible . Nerve impulses generated by the inner ear that are sent to the occipital lobe of the brain via the auditory nerve.

Tumor (Concept and General)

Why tumors grow? Tumors grow because their cells multiply constantly. Therefore, the formation, autonomous and independent organization that is not related to the body and is not of itself rather than in relation to nutrition. A tumor on the body behaves as something strange: the cost of their lives as well as parasites, taking from it the necessary nutrients. Growth is generally limited, as only a few cases up to the park. The tumor, therefore, infinite growth neoformations autonomous, ie not connected to the body in an organic-based. The core of this definition is precisely the autonomy of tumor formation.

All the cells of our bodies can grow with tumor phenotypes, albeit in very different degrees. So, for example, connective tissue and epithelial tumors are often, if not go to the nerve cells. Many tumors formed only by a cloth, for example, joints, cartilage or muscle, the other two networks, for example, epithelial tissue, the other with a variety of networks. In the latter case, the different species of cells in a tumor can be set as they would in normal circumstances. Then it is easy to identify its origin. But they also can grow differently: the interstitial cells forming substances can usually proliferate in tumors without training them. Established tumors, and then, only with the cells and corresponding tissue from embryos in difficult circumstances to recognize this source.

Conceptual distinction made ​​here between self-neoplastic cell growth in embryos regeneration, and hyperplasia, especially compared to the neoplasm tumor cells, can be implemented with such precision in all cases.

12/07/2012

Semicircular Canal

Semicircular canals are three small tubes, closed loop projecting from the front of the inner ear, three semicircular shape: the previous channel, horizontal and then. Each has a diameter of about 0.8 mm and is filled with a fluid called endolymph. The role of the semicircular canals is to maintain balance and spatial orientation, the sensory cells of the hair, which is related to the vestibular nerve fibers that transmit impulses to the brain via the auditory nerve.

Hemosiderosis

Hemosiderosis calls for storing large amounts of hemosiderin in the organ. Hemosiderin is a protein that stores iron in the body, is a derivative of hemoglobin released during hemolysis (destruction of erythrocytes). Hemosiderosis be recognized macroscopically and in the liver, spleen, pancreas, lymph nodes, etc., ochraceous color. Given to these organs. Histology mainly hemosiderin granules in the cells of the reticuloendothelial system, but also in liver cells in the epithelial cells uriniferous tubes (nephrons, etc.).

Hemosiderosis can be observed as a result of repeated blood transfusions are very broad (transfusional Siderosis) and diseases accompanied by intense blood damage, especially in pernicious anemia. In the lungs also saw marked hemosiderosis, as a result of stasis in the smaller circle has taken a lot of small volume bleeding. Alveolar epithelial then phagocytosed red blood cells to form hemosiderin. When they were expelled in sputum, which is the so-called cardiac cells (cell lesions of the valve), the process is particularly seen in patients with heart valve lesions (mitral valve disease).

Chickenpox

Chickenpox is a rash illness of acute, infectious, fever. The rash consists of small particles, the part that turns into vesicles dried without flowing or ulceration. This disease affects children and is caused by the varicella zoster virus. It is highly contagious and spreads through the air exhaled by the patient, without the need for direct contact with it. Chickenpox begins suddenly, without prodromal manifestations with fever, generalemente of 38 ° (often less than 39 °). The rash usually appears first on the face and scalp, and then served on the trunk and extremities. After several hours, the stains become transparent vesicles surrounded by hyperemic halo.

pathology
Bile, which is a measure, lentil unilokular not multilocular (so not emptied the entire contents immediately vesicles to puncionarla) but. Serum vesicles contain some leukocytes and staphylococci often. After one or two days, where the temperature is gradually decreased, the vesicles dried and formed a small central depression. Drying gallbladder verified after becoming the first item and then cloudy yellowish, dry scab forms, which comes after eight to ten days.

treatment 
Because chicken pox is caused by a virus, antibiotics are not effective. Therefore, the limited treatment to relieve symptoms. The prognosis is good in 99% of cases and leaves immune diseases.

Hemochromatosis

Hemochromatosis is a recessive inherited condition characterized by changes in iron metabolism, leading to large accumulation in the body tissues of iron-containing protein called hemosiderin, which is a byproduct of hemoglobin produced hemolysis. Therefore, hemochromatosis causes excessive iron in the body. Consequently, there are also tanks lipid pigment granules called lipofuscin, in intestinal smooth muscle found some excessive lipofuscin and melanin in the skin, so it has a chocolate-brown. Symptoms of hemochromatosis are: weight loss, fatigue and general weakness, heart palpitations, agitation, etc..

treatment 
For patients suffering from hemochromatosis is an iron overaccumulation treated felbotomías practicándoseles, which were removed by the blood of patients, in the same way that blood taken from blood donors. This is done once or twice a week. Phlebotomy accompanied by a diet low in iron.

Gaucher Disease

Gaucher disease is a rare disease characterized by the deposition of fatty molecules called cerebrosides, in cells of the reticuloendothelial system and can affect various organs, including the liver, spleen, bones and central nervous system. Gaucher disease is hereditary, irregular dominant character, and affects infants, children and adolescents. This lipid accumulation due to absence of the enzyme called glucocerebrosidase, which acts with cerebrosides decay, thereby preventing precipitation or accumulation of these cells. The lack of this enzyme is caused by mutations in a gene located on chromosome 1. This condition was first described by French physician Philippe Gaucher in 1882.

The main symptoms of Gaucher disease is an enlarged liver and spleen, bone weakness (with severe pain in the bones), nervous system damage, and anemia. Effective treatment involves the application of Gaucher disease, endovenous, of the enzyme glucocerebrosidase, which is obtained from the placenta or recombinant DNA imiglucerasas.

 There are three recognized forms of the disease: type I, II and III. Type I is the most common form, occurs at any age and the symptoms are more docile and attacks the nervous system. The type II only occurs in children and attacks the nervous system. The type III usually begins in childhood and also showed symptoms of Type I and II, and come in an average of one per thousand births cicuenta.

Middle Ear

The middle ear is the part of the auditory system that lies between the outer ear and the inner ear. It consists of the eardrum and a chain of three tiny bones that transmit vibrations from the eardrum. These bones are: hammer, anvil and stirrup, united by cartilage. The eardrum is a thin membrane composed of translucent connective tissue and epithelial acoustic vibrations picked up from the outside and sends the hammer, anvil and stirrup, which in turn sends them to the inner ear through the oval window. The function of the middle ear is, therefore, receive and transmit sound waves from the outer to the cochlea, located in the inner ear.